Kiyoshi Okuyama
Japan
Research Article
Factorial Analysis on Individual Variability of Tacrolimus Extended-
Release Formulation Pharmacokinetics in the Early Period after Renal
Transplantation-Factors for AUTL/AUC Decrease
Author(s): Yuki Nakamura, Hironori Takeuchi, Hitoshi Iwamoto, Tatsunori Toraishi, Osamu Konno, Yu Kihara, Takayoshi Yokoyama, Toshihiko Hirano, Kiyoshi Okuyama, Hiroaki Katayama, Takashi Kawaguchi, Sakae Nezaki and Shigeyuki KawachiYuki Nakamura, Hironori Takeuchi, Hitoshi Iwamoto, Tatsunori Toraishi, Osamu Konno, Yu Kihara, Takayoshi Yokoyama, Toshihiko Hirano, Kiyoshi Okuyama, Hiroaki Katayama, Takashi Kawaguchi, Sakae Nezaki and Shigeyuki Kawachi
Background: We have often observed that the blood trough concentration (Ct) of the once-daily, prolonged-release formulation of tacrolimus (Graceptor®; GRC) becomes unstable, and it is difficult to adjust it in the early period after transplantation. Consequently, we compared the relationships between pharmacokinetic parameters and influencing factors in a group of GRC-treated patients compared with those in a group of Prograf® (PRG)-treated patients. Methods: The study included 8 patients who were newly treated with GRC and 44 patients who were newly treated with PRG. We performed 24-hour therapeutic drug monitoring to compare the relationships between pharmacokinetic parameters, including the area under the curve (AUC), the ratio of the area under the trough level (AUTL)/AUC to indicate the relationships among AUCs, peak concentration (Cp), and C.. View More»
