Journal of Pharmacovigilance

Kevin Yamashiro

Publications

• Research Article
  Assessing Risks of Impaired Healing and Osteomyelitis Associated with Bisphosphonates Using FDA Adverse Event Reporting System (FAERS)
  Author(s): Amie Cai, Ana Hincapie, Kevin Dong, Wendy Chaing, Tibebe Woldemariam, Xiaodong Feng, Kevin Yamashiro and Bin GuanAmie Cai, Ana Hincapie, Kevin Dong, Wendy Chaing, Tibebe Woldemariam, Xiaodong Feng, Kevin Yamashiro and Bin Guan
  
  Objective: Bisphosphonates are the leading class of drugs to prevent and treat osteoporosis. Numerous cases of bisphosphonates related to bone necrosis and bone fractures have been reported. In this study the risks of impaired healing and osteomyelitis associated with bisphosphonates were assessed using case reports submitted to the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS). Methods: Using FAERS the adverse events reports from the first quarter of 2004 to the second quarter of 2012 associated with bisphosphonates and non-bisphosphonates anti-osteoporosis drugs were generated and evaluated. Standardized pharmacovigilance tools were applied to detect the signal of impaired healing and osteoporosis. Results:.. View More»
  DOI: 10.4172/2329-6887.1000158

  Abstract PDF