Journal of Blood Disorders & Transfusion

Ken Takase

Publications

• Research Article
  Transfusion of ABO-Incompatible HLA-Matched Platelets as Support for Patients with Acute Myeloid Leukaemia Undergoing Chemotherapy
  Author(s): Satoshi Yamasaki, Junko Fujimoto, Kentaro Kohno, Masanori Kadowaki, Sachiko Matsunaga, Ken Takase and Seiichi OkamuraSatoshi Yamasaki, Junko Fujimoto, Kentaro Kohno, Masanori Kadowaki, Sachiko Matsunaga, Ken Takase and Seiichi Okamura
  
  Background: ABO-incompatible human leukocyte antigen (HLA)-matched platelets are used to manage thrombocytopenic patients with anti-HLA-A and/or anti-HLA-B (HLA-A/B) antibodies when ABO-identical donors are not available. This study assessed the effectiveness of ABO-incompatible HLA-matched platelets in an unselected group of patients with acute myeloid leukaemia (AML) undergoing cytotoxic chemotherapy. Material and Methods: The study cohort consisted of 12 AML patients undergoing cytotoxic chemotherapy and administered HLA-matched single donor platelet transfusions. Patients positive for anti-HLA-A/B antibodies were defined as candidates for HLA-matched platelet transfusion. The effectiveness of platelet transfusions was determined by measuring corrected count increments (CCIs). Results: The 12 patients received a tot.. View More»
  DOI: 10.4172/2155-9864.1000344

  Abstract PDF