Journal of Thrombosis and Circulation: Open Access

Kelly S

Publications

• Research Article
  Effects of Baseline Platelet Reactivity on Thrombolysis in Myocardial Infarction Flow and Ischemic Time in Fibrinolysis-treated ST Elevation Myocardial Infarction Patients
  Author(s): Sin P, Yang A, Pon Q, Lavoie A, Crawford JJ, Harenberg S, Zimmermann RH, Booker J, Kelly S, Lavi S, Cantor WJ, Mehta SR, Bagai A, Goodman SG, Cheema A and Dehghani PSin P, Yang A, Pon Q, Lavoie A, Crawford JJ, Harenberg S, Zimmermann RH, Booker J, Kelly S, Lavi S, Cantor WJ, Mehta SR, Bagai A, Goodman SG, Cheema A and Dehghani P
  
  Objective: Thrombolysis in Myocardial Infarction (TIMI) flow in ST-Elevation Myocardial Infarction (STEMI) is aprognostic predictor that is directly influenced by duration of culprit artery occlusion; ischemic time. It is unknownwhether platelet reactivity measured by P2Y12 reaction unit (PRU) is affected by ischemic time or predictive of TIMIflow. Our objectives were to examine the effect of baseline PRU on TIMI flow and on ischemic time. Methods: Between May 2014 and August 2016, the study included 144 patients between four sites undergoingpercutaneous coronary intervention (PCI) within 24 hours of tenecteplase, aspirin and clopidogrel for STEMI. TheVerifyNow® Assay measured baseline PRU prior to angiography. Ischemic time was defined as the duration betweenindex symptom onset and tenecteplase administration. Kruskal-Wallis H test was .. View More»
  DOI: 10.4172/2572-9462.1000128

  Abstract PDF