Kamal Kiran Mukkavalli
India
Research Article
Importance of Gene Polymorphisms in Renal Transplant Patients to Prevent Post Transplant Diabetes
Author(s): Kiran Kumar Vattam, Sireesha Movva, Imran Ali Khan, Pavani Upendram, Kamal Kiran Mukkavalli, Pragna Rao and Qurratulain HasanKiran Kumar Vattam, Sireesha Movva, Imran Ali Khan, Pavani Upendram, Kamal Kiran Mukkavalli, Pragna Rao and Qurratulain Hasan
Objective: Post transplantation diabetes mellitus (PTDM) is a major complication associated with kidney transplantation due to the immunosuppressive therapy. Defects in insulin secretion play a pivotal role in the pathogenesis of PTDM and zinc also playsan important role in all process of insulin trafficking, i.e. synthesis, storage and secretion. Gene polymorphisms in the transcription factor 7-like 2 (TCF7L2) and zinc transporter protein member 8(SLC30A8) was reported to be associated with type 2 diabetes, possibly associated with an insulin secretion defect. The aim of this study was to investigate the association between genetic variations in TCF7L2, SLC30A8 and PTDM in renal allograft recipients. Method: PCR and RFLP based genotyping of TCF7L2 (rs#7903146) and SLC30A8 (rs#13266634) polymorphisms were carried out in 364 individuals which included .. View More»
