Journal of Clinical & Experimental Pharmacology

Jyothi I

Publications

• Research Article
  Melatonin Release and Polysomnographic Architecture in Patients with Mild to Moderate Depression
  Author(s): Jyothi I, Ilango K, Satish Kumar RC, Vasanth K and Dubey GPJyothi I, Ilango K, Satish Kumar RC, Vasanth K and Dubey GP
  
  Objectives: The association of serum melatonin levels with polysomnographic sleep parameters were investigated in mild to moderate depressed patients. Methods: Seventy patients with mild to moderate depression (mean age 49.43 ± 6.70) were selected in the study. All patients underwent two successive overnight polysomnography recordings. Venous blood samples were obtained from the patients of two groups at 21:00 h and 6:00 h before and after performing polysomnography. Serum was separated and kept at -80°C. The serum melatonin levels were analysed using microplate reader. Results: Early morning release of melatonin was significantly correlated with sleep latency (P=0.0026, r=0.4630), [CI=0.3249 to 1.426], sleep efficiency (P=0.049, r=0.3123), [CI=0.01253 to 0.3180] and total sleep time (P=0.006, r=0.516), .. View More»
  DOI: 10.4172/2161-1459.1000244

  Abstract PDF