Journal of Vaccines & Vaccination

Journal of Vaccines & Vaccination
Open Access

ISSN: 2157-7560

Junxin Li

Junxin Li


  • Review Article
    Natural Killer T Cell Based Immunotherapy
    Author(s): Priyanka B Subrahmanyam, Wenji Sun, James E East, Junxin Li and Tonya J WebbPriyanka B Subrahmanyam, Wenji Sun, James E East, Junxin Li and Tonya J Webb

    Natural killer T (NKT) cells play an important immunoregulatory role and are thought to bridge the innate and adaptive immune responses. Following activation through cognate interactions with lipid antigen presented in the context of CD1d molecules, NKT cells rapidly produce a plethora of cytokines and can also mediate cytotoxicity. Due to their potent effector functions, extensive research has been performed to increase our understanding on how to effectively modulate these cells. In fact, NKT cell agonists have been used as vaccine adjuvants to enhance antigen specific T and B cell responses to infections and malignancy. In this review, we will focus on recent advances in NKT cell-based vaccination strategies. Given the role that NKT cells play in autoimmune disease, infectious diseases, cancer, transplant immunology and dermatology, it is important to understand how to effectively .. Read More»
    DOI: 10.4172/2157-7560.1000144

    Abstract PDF

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