Journal of Blood Disorders & Transfusion

Jun Takebe

Publications

• Research Article
  25% Albumin Infusion Maintains Antithrombin III (AT) Activity after AT Agent Administration in Critically Ill Patients with Disseminated Intravascular Coagulation (DIC)
  Author(s): Mayuki Aibiki, Noriyasu Fukuoka, Shiro Bando, Hironori Matsumoto, Muneaki Ohshita, Souichi Maekawam and Jun TakebeMayuki Aibiki, Noriyasu Fukuoka, Shiro Bando, Hironori Matsumoto, Muneaki Ohshita, Souichi Maekawam and Jun Takebe
  
  Objective: To report for the first time critically ill patients with disseminated intravascular coagulation (DIC) in whom the infusion of 25% albumin solution produces remarkable elevations in plasma antithrombin III (AT) activities after administration of AT agents. Design: A prospective observational study. Interventions: 1) Plasma AT activities were serially measured in DIC patients after AT administration, enable us to analyze their pharmacokinetics; 2) Comparisons of AT activities between two groups of receiving AT agent with or without the infusion of 25% albumin solution; 3) in vitro examinations were conducted to define whether albumin application itself would influence directly an AT measurement system using samples already determined the levels of AT activities. Methods and main results: Twenty consecutive critical patien.. View More»
  DOI: 10.4172/2155-9864.1000208

  Abstract PDF