Cardiovascular Pharmacology: Open Access

Johnsen J

Publications

• Research Article
  Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the In Vitro Rabbit Heart
  Author(s): Salman R, Johnsen J, Lassen TR, Hansen RS, Bøtker HE and Schmidt MRSalman R, Johnsen J, Lassen TR, Hansen RS, Bøtker HE and Schmidt MR
  
  Background: Remote Ischemic Preconditioning (rIPC) and the antiarrhythmic peptide analogue, Rotigaptide (ZP123), protects against myocardial ischemia-reperfusion injury through potentially similar mechanisms. We aimed to study whether the cardioprotective effects of Rotigaptide and rIPC interacts. Methods: We used male New Zealand White rabbit hearts mounted in a Langendorff system and exposed to 30 min of global no-flow ischemia and 120 min of reperfusion. A total of 48 rabbits were randomized into 6 groups: control (n=6), Rotigaptide (1 μM) before (n=9) or after (n=9) ischemia, rIPC (n=7), rIPC+Rotigaptide before (n=9) or after (n=8) ischemia. rIPC was induced by four cycles of 5-min ischemia and reperfusion on the left hind limb achieved by intermittent tourniquet occlusion. Primary endpoint was infarct size measured by tetrazolium staining. Results: rIPC reduced infarct size co.. View More»
  DOI: 10.4172/2329-6607.1000209

  Abstract PDF