John SD Chan
Université de Montréal, Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM),
Tour Viger, 900 Saint Denis Street, Montreal, Quebec, H2X 0A9
Canada
Mini Review
Angiotensin-(1-7): A Novel Peptide to Treat Hypertension and Nephropathy in Diabetes?
Author(s): Ranjit Singh Padda, Yixuan Shi, Chao-Sheng Lo, Shao-Ling Zhang and John SD ChanRanjit Singh Padda, Yixuan Shi, Chao-Sheng Lo, Shao-Ling Zhang and John SD Chan
The renin-angiotensin system (RAS) plays a pivotal role in mammalian
homeostasis
physiology. The RAS can be delineated into a classical RAS (the pressor arm) including angiotensinogen (Agt), renin, angiotensin-converting enzyme (ACE), angiotensin II (Ang II) and angiotensin type 1 receptor (AT1R), and a counterbalancing novel RAS(the depressor arm) including Agt, renin, angiotensin-converting enzyme-2 (ACE-2), angiotensin-(1-7) (Ang 1-7) and Ang 1-7 receptor (or Mas receptor (MasR)). Hyperglycemia (diabetes) induces severe tissue oxidative stress, which stimulates the pressor arm of the renal RAS axis and leads to an increase in ACE/ACE-2 ratio, with excessive formation of Ang II. There is a growing body of evidence for beneficial effects of the depressor arm of RAS (ACE-2/Ang 1-7/MasR) axis in diabetes, hypertension and several other diseased conditions. Evidence .. View More»
