Biology and Medicine

Johanna Rajkumar

Publications

• Research Article
  Inhibition of PKCβ Mediates Cardioprotective Activity of Ambrex against Isoproterenol-Induced Myocardial Necrosis: in vivo and in silico Studies
  Author(s): Rekha Ravindran, Sriram Kumar, Johanna Rajkumar, Sujata Roy, Sekar Sathiya, Chidambaram Saravana Babu and Mohammad Javed EqubalRekha Ravindran, Sriram Kumar, Johanna Rajkumar, Sujata Roy, Sekar Sathiya, Chidambaram Saravana Babu and Mohammad Javed Equbal
  
  Aims and objectives: The current study characterized the morphology of Ambrex formulation by Scanning Electron Microscopy and assessed its cardioprotective activity against Isoproterenol (ISPH)-induced myocardial necrosis in rats by biochemical and histopathological evaluations, and also attempted to predict the prospective protein-targets of Ambrex and the signaling pathway that mediates this activity through molecular docking approach. Materials and methods: Sprague–Dawley male rats (4 groups, 6 rats per group) chosen for the current study were acclimatized to the laboratory conditions for 7 days prior to actual treatment; they were pretreated with Ambrex (40 mg/kg b.wt/day, p.o) everday for 21 days and then intoxicated with ISPH (85 mg/kg b.wt, s.c) on day-20 and 21 to experimentally induce myocardial necrosis. The extent of ISPH-in.. View More»
  DOI: 10.4172/0974-8369.1000442

  Abstract PDF