Journal of Stem Cell Research & Therapy

Jie Zhang

Publications

• Research Article
  Comparison of Bone Marrow-derived Mononuclear Cells vs. Mesenchymal Stem Cells in Protecting Random-pattern Skin Flap Survival in Rats
  Author(s): Peng Xu, Yang Lu, Zhenxing Wang, Jie Lian, Guangdong Zhou, Wei Liu, Yilin Cao, Wei Li and Jie ZhangPeng Xu, Yang Lu, Zhenxing Wang, Jie Lian, Guangdong Zhou, Wei Liu, Yilin Cao, Wei Li and Jie Zhang
  
  Both cultured Bone Marrow Mesenchymal Stem Cells (BMSCs) and non-cultured Bone Marrow Mononuclear Cells (BM-MNCs) can improve random-pattern skin flap survival. However, whether prior culture expansion of bone marrow cells is beneficial for this therapy remains unclear. In the current study, the protective effects of BM-MNCs and BMSCs derived from identical bone marrow aspirates were compared in a random-pattern skin flap rat model. The mean skin flap survival rates were 71.6 ± 8.4% in the BM-MNC-treated group and 66.2 ± 3.1% in the BMSCtreated group, both of which were significantly higher than the control group (55.9 ± 3.4%). The protective effects were confirmed by blood perfusion analysis and vessel density assay. However, no significant difference was observed between the cell transplanted groups. These results indicate that the current method for pre-culture.. View More»
  DOI: 10.4172/2157-7633.1000355

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