Journal of Diabetes & Metabolism

ISSN - 2155-6156

Jessica L Sarvas

Publications
  • Review Article
    The IL-6 Paradox: Context Dependent Interplay of SOCS3 and AMPK
    Author(s): Jessica L Sarvas, Neelam Khaper and Simon J LeesJessica L Sarvas, Neelam Khaper and Simon J Lees

    Insulin resistance is the principle step towards the progression of type 2 diabetes, and has been linked to increased circulating levels of cytokines, leading to chronic low-grade inflammation. Specifically, in chronic disease states increased interleukin-6 is thought to play a critical role in the regulation of insulin resistance in the peripheral tissues, and has been used as a marker of insulin resistance. There is also an endogenous up-regulation of IL-6 in response to exercise, which has been linked to improved insulin sensitivity. This leads to the question “how can elevated IL-6 lead to the development of insulin resistance, and yet also lead to increased insulin sensitivity?” Resolving the dual role of IL-6 in regulating insulin resistance/sensitivity is critical to the development of potential therapeutic interventions. This review summarizes the literature on the.. View More»

    DOI: 10.4172/2155-6156.S13-003

    Abstract PDF

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