Jean-Claude Lavoie
Université de Montréal, Research Center,
CHU Sainte-Justine, 3175 Côte Ste-Catherine, Montreal, QC, H3T 1C5
Canada
Research Article
Blood Glutathione Peroxidase Activity in Relation with the Risk of Cardiovascular Diseases in Obese Women
Author(s): Marie-Eve Lavoie, Rémi Rabasa-Lhoret, Sophie Ziai and Jean-Claude LavoieMarie-Eve Lavoie, Rémi Rabasa-Lhoret, Sophie Ziai and Jean-Claude Lavoie
Objective: Oxidative stress plays a role in obesity-related diseases. We hypothesize that abnormalities of the glutathione system are associated with the initial phase leading to development of cardiometabolic abnormalities such as cardiovascular diseases and type 2 diabetes in apparently healthy obese women. By measuring different glutathione parameters, we expect to find a dichotomy that can discriminate between obese women who have such sub-clinical abnormalities. Subjects: This is a cross-sectional analysis in 59 postmenopausal obese women. Total blood glutathione, glutathione peroxidase (GPx) and glutathione reductase activity, blood lipids, apolipoprotein B-100 (apoB), fasting and area under the curve (AUC) for glycemia and insulinemia during an oral glucose tolerance test, insulin sensitivity m.. View More»
