Journal of Data Mining in Genomics & Proteomics

Jaya Padmanabhan

Publications

• Research Article
  Interacting Proteins and Pathways in Human Alzheimer’s Disease Brain Tissue Using Mass Spectrometry
  Author(s): Malathi Narayan, Lisa Kirouac, Dale Chaput, Stanley Stevens, Jaya Padmanabhan and Umesh K JinwalMalathi Narayan, Lisa Kirouac, Dale Chaput, Stanley Stevens, Jaya Padmanabhan and Umesh K Jinwal
  
  Alzheimer’s disease (AD) is the most common form of dementia and the 6th leading cause of death in the United States. The major pathological hallmarks observed in AD include the formation of intracellular neurofibrillary tangles comprised of phosphorylated forms of the microtubule associated protein tau, and the deposition of extracellular plaques composed of amyloid beta. Cdc37 is a co-chaperone of Hsp90, which recruits client kinases to the Hsp90 complex for folding and stabilization. It has been previously shown that Cdc37 can not only bind and preserve tau, but also stabilize kinases that can phosphorylate tau. The goal of the current study was to identify novel Cdc37- interacting proteins in human AD tissue compared to normal tissue using an immunoprecipitation-based approach combined with mass spectrometry. We identified 39 unique proteins that interacted with Cdc37 in AD .. View More»
  DOI: 10.4172/2153-0602.1000193

  Abstract PDF