Journal of Diabetes & Metabolism

ISSN - 2155-6156

Jake Carrion

Jake Carrion

Tanzania

Publications
  • Research Article
    Identification of Differentially Expressed Genes in Pancreatic Regulatory T-Cell Survival
    Author(s): Jake Carrion and Michael CarrionJake Carrion and Michael Carrion

    Objective: Many current Diabetes treatments cause broad-based immunodeficiency , though future organspecific therapies may be developed by exploiting genotypic differences found in regulatory T cell (Treg) subpopulations. This study goaled to determine genes preferentially expressed in pancreatic Tregs relative to other Treg subpopulations, tissues, and immune cells to serve as targets in Diabetes therapy. Methods: Multi-step microarray analysis using GenePattern Software identified genes specific to pancreatic Tregs relative to Tregs in other tissues and to other immune-cell populations. Functional analysis of identified genes was performed using BioGrid and String Databases. Microarray datasets (n=2236) curated from the NCBI GEO database were processed (via RMA normalization, outlier-array exclusion, and global median transformation) to confirm the specificity of.. View More»

    DOI: 10.4172/2155-6156.1000612

    Abstract PDF

Relevant Topics

Top