Modern Chemistry & Applications

Ishaq A Zaafarany

Publications

• Research Article
  Kinetics and Mechanistic Approach to Palladium (II)-Catalyzed Oxidative Deamination and Decarboxylation of Leucine and Isoleucine by Anticancer Platinum (IV) Complex in Perchlorate Solutions
  Author(s): Ahmed Fawzy, Ishaq A Zaafarany, Hatem M Altass, Ismail I Althagafi and Tahani M BawazeerAhmed Fawzy, Ishaq A Zaafarany, Hatem M Altass, Ismail I Althagafi and Tahani M Bawazeer
  
  Oxidations of two aliphatic α-amino acids (AA), namely, leucine and isoleucine by hexachloroplatinate (IV) as an anticancer platinum (IV) complex has been studied using a spectrophotometric technique in perchlorate solutions in the presence of palladium (II) catalyst at a constant ionic strength of 1.0 mol dm-3 and at 25°C. The reactions did not proceed in the absence of the catalyst. The reactions of both amino acids showed a first order dependence on both [PtIV] and [PdII], and less than unit order dependences with respect to both [AA] and [H+]. Increasing ionic strength and dielectric constant of the reactions medium increased the rates of the reactions. A probable oxidations mechanism has been suggested and the rate law expression has been derived. Both spectral and kinetic evidences revealed formation of 1:1 intermediate complexes between AA and PdII before the rate-con.. View More»
  DOI: 10.4172/2329-6798.1000182

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