Journal of Biomolecular Research & Therapeutics

Journal of Biomolecular Research & Therapeutics
Open Access

ISSN: 2167-7956

+44 7480022449

Iqbal RK

Iqbal RK
Institute of Molecular Biology and Biotechnology,

  • Review Article
    Recombinant Antibodies and Vaccines for Viruses
    Author(s): Iqbal RKIqbal RK

    Immunity produced when variable, diverse, and joining exons recombine and form diverse B-cell receptors. Somatic rearrangement of immunoglobulin genes termed VDJ recombination. This activity is controlled by RAG1 and RAG2 proteins, binds to the signal sequences and start cleavage. Double stranded breaks are produced by ROS, Nuclear enzymes and ATM. RAG protein induces cleavage activity. Segments exchange by CSR. After cleavage activity shuffling of segments occurs. TDT cause gain or loss of nucleotide bases. AID and RAG begins the process of CSR that shuffle exons of constant region. The core of NHEJ have catalytic subunit (DNA-Pkcs). Ku-DNA complex is important for the attachment of nuclease, polymerase and ligase of NHEJ. RAG2 with histone H3K4Me3 start recombination activity. HMG1 and HMG2 promote synapsis and cleavage. RNA Helicase of the DExD\H induces conformational changes. ZnA.. Read More»
    DOI: 10.35248/2167-7956.19.8.169

    Abstract PDF

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