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Hua He
Hua He
Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education,
Chongqing 400010
China
Publications
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Review Article
Global Analysis of Proteomics for Discovery of Biomarkers in Hepatocellular Carcinoma
Author(s): Hong Li, Jiangbei Yuan, Fang Zhai, Jianqiang Zhang, Hua He and Xuefeng XiaHong Li, Jiangbei Yuan, Fang Zhai, Jianqiang Zhang, Hua He and Xuefeng Xia
Hepatocellular Carcinoma (HCC) is a most lethal malignancy. At first presentation, patients often already have advanced disease, and their treatment options for cure are very limited. Measurable biomarkers for early diagnosis of HCC are urgently needed to prolong the median over-all survival rate and reduce therapeutic expenditures. Proteomics is a powerful analytical technique that has been widely applied to search for cancer biomarkers, including in HCC. High-sensitivity, high-throughput, and non-invasive technologies should be capable of contributing to early diagnosis of HCC. In this review, we provide a flow scheme for proteomic study in HCC, and an overview of technical approaches for protein quantification. In addition, we present a broad summary of the HCC biomarkers proposed by studies in recent years, which have used various quantitative proteomic approaches. .. View More»
DOI: 10.4172/2167-0889.1000202