Hoda EA Farid
Saudi Arabia
Research Article
Antidepressant-like Effects of Aqueous Extract of Salvadora persica in Rat Model of Depression
Author(s): Kholoud S Ramadan, Hoda EA Farid and Raya MM AlmarashiKholoud S Ramadan, Hoda EA Farid and Raya MM Almarashi
Salvadora persica (SP) has been used as a medicinal purpose among global Muslim community. Various phytochemical studies on SP reported the presence of saponins, flavonoids, steroids, phenols and tannins. Flavonoids are responsible for antimicrobial, antiallergic, antioxidant, antiradial, anti-inflammatory and antiproliferative activity. The present study was carried out to evaluate the antidepressant activity of aqueous extract of SP on forced swimming test on male albino rats after four weeks treatment. The effect was assessed by immobility time, body weight, vital organ weight, blood glucose, and degree of DNA fragmentation that might happen in leukocyte due to depression. These activities were tested at dose of 900 mg/kg extracts of SP administered orally for 28 successive days. Rats were divided into two groups (12 animals/group): control group (.. View More»
