Journal of Data Mining in Genomics & Proteomics

Hideshi Yokoyama

Publications

• Research Article
  Molecular Modeling and Simulation of Human Stomatin and Predictions for its Membrane Association
  Author(s): Yosuke Kondo, Hideshi Yokoyama, Ikuo Matsui and Satoru MiyazakiYosuke Kondo, Hideshi Yokoyama, Ikuo Matsui and Satoru Miyazaki
  
  Stomatin is a membrane protein in human red blood cells. The crystal structure, in which the monomeric stomatin from the hyperthermophilic archaeon Pyrococcus horikoshii consists of the α/β domain and the C-terminal α-helical segment, forms a homo-trimer, and stomatin is organized into further high order homo-oligomeric complexes, comprising 9- to 12-mers. To better understand the molecular functions of stomatin, the hypothesis how human stomatin oligomerizes and is associated with cell membranes should be validated. Here, we report what conformations can be generated from the stomatin structure by estimating the flexibility of α-helical segments of human stomatin. And we also simulate how the oligomeric structure of human stomatin interacts with cell membranes. The results showed that the α-helical segments can make flexible movements; the α-helical.. View More»
  DOI: 10.4172/2153-0602.1000216

  Abstract PDF