Modern Chemistry & Applications

Hardeep S Saluja

Publications

• Research Article
  Evaluation of the Physicochemical Properties of a Novel Antimalarial Drug Lead, Cyclen Bisquinoline
  Author(s): Mohammad Faisal Hossain, Amoyaw PNA, Hardeep S Saluja and Faruk Khan MOMohammad Faisal Hossain, Amoyaw PNA, Hardeep S Saluja and Faruk Khan MO
  
  The purpose of this study was to evaluate physicochemical properties of an antimalarial drug lead, 4,10-bis(7- chloroquinoline)-1,4,7,10-tetraazacyclododecane (Cyclenbisquinoline; CNBQ) and its hydrochloride salt. The free base (FB) of CNBQ is a white polymorphic crystalline powder and the salt is off-white powder. The application of standard experimental protocol including differential scanning calorimetric (DSC) analyses revealed that the FB has at least four different crystalline polymorphs melting at 166°C, 178°C, 195°C and 234°C, respectively, and the salt showed a broad endotherm, suggesting it to be amorphous in nature. Equilibrium solubility and stability of both FB and salt were carried out in different mediums, and samples were analyzed using reverse phase-high performance liquid chromatography (RP-HPLC). The compound is highly hydrophobic; however, salt .. View More»
  DOI: 10.4172/2329-6798.1000181

  Abstract PDF