Journal of Blood Disorders & Transfusion

Hanspeter Rottensteiner

Publications

• Short Communication
  Low Incidence of Anti-CD36 Antibodies in Acquired Thrombotic Thrombocytopenic Purpura
  Author(s): Silvia Ferrari, Verena Schitt, Hanspeter Rottensteiner and Friedrich ScheiflingerSilvia Ferrari, Verena Schitt, Hanspeter Rottensteiner and Friedrich Scheiflinger
  
  Acquired idiopathic thrombotic thrombocytopenic purpura (TTP) is characterized by severe ADAMTS13 deficiency due to the presence of autoantibodies against ADAMTS13. Previous studies using Western blot and immunoprecipitation techniques detected autoantibodies against the membrane antigen CD36 in over 50% of acquired TTP patients. The pathological or clinical significance of this apparent correlation however remains elusive. We reevaluated this potential link by analyzing a cohort of 76 patients with acute acquired TTP for the presence of anti-CD36 autoantibodies using a newly developed enzyme-linked immunosorbent assay (ELISA). Circulating anti-CD36 antibodies were detected in only 4/76TTP patients and 2/63 healthy donors, with no statistically significant difference (p=0.096) in antibody levels between the two populations. The gross discrepancy in the frequency of anti-CD36 antibodie.. View More»
  DOI: 10.4172/2155-9864.1000146

  Abstract PDF