Cardiovascular Pharmacology: Open Access
Open Access
ISSN: 2329-6607
ISSN: 2329-6607
Hanif Tabesh
West Indies
Research Article
Cardiac Effects of Glucagon-Like Peptide 1 with Chitosan-Based Scaffold after Inducing Myocardial Infarction in Dogs
Author(s): Sam Zeraatian, Abbas Salehiomran, Ruhollah Mehdinavaz Aghdam, Seyed Hossein Ahmadi Tafti, Seyed Reza Ghiasi, Nasim Kiaee, Shahram Rabbani, Ali Ghiasedin, Hanif Tabesh and Nazafarin KamalzadeSam Zeraatian, Abbas Salehiomran, Ruhollah Mehdinavaz Aghdam, Seyed Hossein Ahmadi Tafti, Seyed Reza Ghiasi, Nasim Kiaee, Shahram Rabbani, Ali Ghiasedin, Hanif Tabesh and Nazafarin Kamalzade
Aims: Glucagon-like peptide 1 (GLP-1) is one of the new choices in the management of diabetes mellitus because of its glucose regulatory effects. GLP-1 receptors are expressed not only in islet cells, kidney, lung, brain, and gastrointestinal tract, but also in the heart. The cardiac effects of GLP-1 play a major role in the choice to use this treatment, considering the expression of GLP-1 receptors in heart. Degradation by dipeptidyl peptidase-IV (DPPIV) makes GLP-1’s half-life very short. In this study, the cardiac effects of GLP-1 with chitosan-based scaffold as well as the tissue changes after induction of myocardial infarction in canines were evaluated.
Method: Twelve canines of a similar breed and weight were included in this study. They were categorized into three groups: A case group treated with GLP-1 based on a chitosan scaffol.. Read More»
DOI:
10.4172/2329-6607.1000159