Journal of Clinical & Experimental Pharmacology

Journal of Clinical & Experimental Pharmacology
Open Access

ISSN: 2161-1459

+44 1202068036

Guo-Hua Gong

Guo-Hua Gong

No. 1742 Holin he Street, Tongliao 028000, Inner Mongolia
IR Iran

Publications
  • Research Article
    Anti-Aging and Enhanced Physique Activities Research of Astragalus Mongolicus Water Extract in Mice
    Author(s): Li-Jun Yu, Ao Wuliji, Shu-Yin Bao and Guo-Hua GongLi-Jun Yu, Ao Wuliji, Shu-Yin Bao and Guo-Hua Gong

    The present study aimed to investigate the biological activities of Astragalus mongolicus (AM) water extract in mice. Mice intraperitoneally received D-gal 300 mg/kg, and orally administered with AM water extract (6, 12 or 24 g/kg) once daily for 56 days, the results of ethological examination exhibited that D-gal can weaken spatial memory function of mice in the Morris water maze test; further analysis demonstrated that the capacity of oxidative stress mediated by oxidase was enhanced in D-gal-injected mice. The decreased activities of SOD and GSH-Px and the increased activity of CAT could be found in hippocampus induced by D-gal. Based on the results above, we inferred and explored enhanced memory and physique abilities of AM water extract using three mice models (water maze test, swim test and beheaded breathing test), the results exhibited that AM water extract could prolong the s.. Read More»
    DOI: 10.4172/2161-1459.1000175

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