Guillermo Ceballos
School of Medicine of the National Polytechnic Institute,
Mexico
Research Article
Cardiometabolic Alterations in Wistar Rats Induced By an Obesogenic Paigen-Like Diet: Effects of (-) Epicatechin
Author(s): Gabriela Gutiérrez-Salmeán, Elizabeth De Jesús-Torres, Pilar Ortiz-Vilchis, Claudia Vacaseydel, Leticia Garduño-Siciliano, Eduardo Meaney, Francisco Villarreal, Israel Ramírez-Sánchez, Alicia Ortiz, Germán Chamorro-Cevallos and Guillermo CeballosGabriela Gutiérrez-Salmeán, Elizabeth De Jesús-Torres, Pilar Ortiz-Vilchis, Claudia Vacaseydel, Leticia Garduño-Siciliano, Eduardo Meaney, Francisco Villarreal, Israel Ramírez-Sánchez, Alicia Ortiz, Germán Chamorro-Cevallos and Guillermo Ceballos
Background and objective: The Metabolic Syndrome (MS) is suggested to develop from –among other factorsinadequate diet. To explore its pathophysiology, animal models of diet-induced obesity and its comorbidities are often used, although not all of them produce the same cardiometabolic alterations. Regarding novel therapeutic options, (-)-epicatechin (EPI), the most abundant polyphenol in cacao exerts several beneficial effects on MS features. Therefore, we aimed to test the effects of EPI in the cardiometabolic derangements of rats fed with a diet with added, sugar, saturated fat, added with cholesterol and cholate (Paigen-like diet, PD).
Methods: 4 groups of rats were assessed: normal diet (ND); normal diet + EPI (ND+E); Pagen-like diet (PD) and Paigen-like diet + EPI (PD+E, prevention group). EPI was administered by gavage (1 mg/kg d.. View More»
