Biochemistry & Analytical Biochemistry

Grygorieva VN

Publications

• Research Article
  Zoledronic Acid and Its Calcium-contain Complexes in Treatment of Experimental Osteoporosis in Wistar Female Rats
  Author(s): Povoroznyuk VV, Grygorieva VN, Pekhnyo VI, Kozachkova OM and Tsaryk NVPovoroznyuk VV, Grygorieva VN, Pekhnyo VI, Kozachkova OM and Tsaryk NV
  
  The aim was to assess the composition, stability and biological activity of the complexes that are formed in the solution on the interaction of calcium ions with Zolendronic acid (Zol) and study their effects on bone mineral density (BMD) indexes in female rats with experimental osteoporosis. 40 reproductive Wistar rats with systemic osteoporosis which was modeled by oophorectomy were under the study. Animals were divided into 4 groups (I – did not receive any treatment with bisphosphonates, only sufficient consumption of calcium and vitamin D (Ca-D); II – receive single dose of Zol and Ca-D; III – soluble calcium complexes of Zol (Ca-Zol) without additional use of Ca-D; IV – soluble calcium complexes of Zol with Ca-D). BMD and bone mineral content (BMC) of total body and spine were measured before treatment, after 1 and 3 months of observation by X-ray densito.. View More»
  DOI: 10.4172/2161-1009.1000340

  Abstract PDF