Journal of Food Processing & Technology

Griffo TN

Publications

• Research Article
  Alpha-Linolenic Acid Supplementation is Associated with Changes in Inflammatory Markers and Endoplasmic Reticulum Stress in Diabetic Rats
  Author(s): Ferraz RC, Foss-Freitas MC, Vidal TR, Griffo TN, Gonçalves NB, Jordao Jr AA and Foss MCFerraz RC, Foss-Freitas MC, Vidal TR, Griffo TN, Gonçalves NB, Jordao Jr AA and Foss MC
  
  Background: The aim of this study was to evaluate the effects of α-linolenic acid (ALA) supplementation on inflammation and endoplasmic reticulum stress (ERS) in streptozotocin induced diabetic rats. Methods: We studied 40 Wistar rats divided into four groups: control, control+ALA, diabetes and diabetes+ALA. The +ALA groups received supplementation of 3 g of ALA from flaxseed, daily for a period of 8 weeks. Measurements of blood glucose levels, serum insulin, lipid profile, serum cytokines (TNF-α, IL-6 and INF-γ) and body weight were performed before and after the ALA supplementation. Protein expression of AKT, IRE1-α, XBP-1, BIP, HSP-70, HSP-90, TNF-α and CHOP were evaluated in liver tissue. Results: The diabetes+ALA group had lower liver and greater epidydimal adipose tissue weight in rela.. View More»
  DOI: 10.4172/2157-7110.1000720

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