Grabiec Marek
Poland
Research Article
Elevation of sE-Selectin Levels from 2-24 Months Following Gestational Diabetes is Associated with Early Cardiometabolic Risk in Non-Diabetic Women
Author(s): Sokup Alina, Ruszkowska Barbara, Góralczyk Krzysztof, Góralczyk Barbara, Grabiec Marek and Rość DanutaSokup Alina, Ruszkowska Barbara, Góralczyk Krzysztof, Góralczyk Barbara, Grabiec Marek and Rość Danuta
Women with previous gestational diabetes (pGDM) represent a high risk group for type 2 diabetes and for cardiovascular disease in the future. The aim of current study was to assess selected parameters of dysfunction of endothelium such as concentration of soluble E-selectin (sE-selectin), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intracellular adhesion molecule-1 (sICAM-1) in women with pGDM. Subjects/Methods: Anthropometric parameters, glucose regulation, insulin resistance, lipid levels, inflammation and soluble plasma endothelial dysfunction. Biomarkers levels were evaluated in 85 women with pGDM and in the control group of 40 patients 2-24 months postpartum. Results: The pGDM group consisted of 67% women with normal glucose regulation (pGDM-N) and 33% with pre-diabetic state (pGDM-P). The body mass index, waist circumference, fasting and 2-h glucose during o.. View More»
