Godfrey BS Iyalomhe
College of Medicine,
Ekpoma
Nigeria
Research Article
A Comparison of the Effects of Amlodipine and Hydrochlorothiazide Monotherapy on Lipid Metabolism in Hypertensive Nigerians with Type 2 Diabetes Mellitus
Author(s): Godfrey BS Iyalomhe, Eric KI Omogbai, Ambrose O Isah, Osigbemhe OB Iyalomhe, Folorunso L Dada and Sarah I IyalomheGodfrey BS Iyalomhe, Eric KI Omogbai, Ambrose O Isah, Osigbemhe OB Iyalomhe, Folorunso L Dada and Sarah I Iyalomhe
Background: Although the association between antihypertensive therapy and lipid profiles is well established, there are very limited reports regarding the same in hypertensive Nigerians with type 2 diabetes mellitus. The aim of this study is to evaluate the extent to which treatment with amlodipine or hydrochlorothiazide would affect lipid panels.
Materials and methods: Forty newly diagnosed hypertensive subjects with controlled type 2 diabetes mellitus aged 43-68 years were randomized to amlodipine and hydrochlorothiazide treatment groups. Each group comprised 20 patients (20 males and 20 females) and they were treated, respectively, with amlodipine 10 mg and hydrochlorothiazide 25 mg, all given once daily for 48 weeks. Body mass index, blood pressure and lipid parameters were evaluated at baseline (week 0) before treatment as well as at the end of 1, 3, 6, 12, 24, 36 and 4.. View More»
