Girum Mekonnen
Tanzania
Research Article
Coronary Endothelial Dysfunction, Obesity and Metabolic Syndrome
Author(s): Julian PJ Halcox, Muhiddin A Ozkor, Girum Mekonnen and Arshed A QuyyumiJulian PJ Halcox, Muhiddin A Ozkor, Girum Mekonnen and Arshed A Quyyumi
Objective To define the impact of metabolic syndrome (MetS) and obesity on coronary vascular function, with the hypothesis that subjects with MetS will have endothelial dysfunction.
Background: Obesity or the metabolic syndrome (MetS) is associated with a higher risk of diabetes and coronary artery disease (CAD). Endothelial dysfunction is a common causal pathway in the initiation and progression of CAD.
Methods: A total of 418 patients (165 obese, 239 MetS) with and without angiographic evidence of CAD underwent coronary vascular function testing by measuring coronary blood flow (CBF) velocity in response to intracoronary infusion of acetylcholine (ACH) and sodium nitroprusside (SNP) and coronary flow reserve with adenosine.
Results: Endothelium-dependent microvascular vasodilation correlated with BMI (r.. View More»
