Journal of Clinical & Experimental Pharmacology

Gerardo Botti

Publications

• Editorial
  Extracellular Matrix Molecules as Targets for Melanoma Therapy
  Author(s): Gerardo Botti, Margherita Cerrone, Annamaria Anniciello, Rossella De Cecio, Paolo Ascierto and Monica CantileGerardo Botti, Margherita Cerrone, Annamaria Anniciello, Rossella De Cecio, Paolo Ascierto and Monica Cantile
  
  Malignant melanoma, between human diseases, represents a best model to study tumor progression process. In fact, during its evolution, a series of events takes place involving several molecular mechanisms associated to both melanocytes transformation and to the surrounding microenvironment, with a prevalent involvement of Extracellular Matrix (ECM). A large series of mechanisms correlated to the activity of these molecules have been studied to establish specific interfering system for target therapies in several human cancers. We suggest that the combination of specific ECM target therapies and immune-therapy, making more efficient the therapeutic approaches for malignant melanoma disease. .. View More»
  DOI: 10.4172/2161-1459.1000e118

  Abstract PDF