Journal of Pharmacovigilance

Genre J

Publications

• Case Report
  Association of CD69 and CD 25 Activation Markers on CD4 and CD8 Cells with Skin Tests in Drug Allergy
  Author(s): Teixeira FM, Vasconcelos LMF, Araújo TS, Genre J, Almeida TLP, Magalhães HIF, Câmara LMC and Nagao-Dias ATTeixeira FM, Vasconcelos LMF, Araújo TS, Genre J, Almeida TLP, Magalhães HIF, Câmara LMC and Nagao-Dias AT
  
  Background: Diagnosis of drug allergy is difficult because few methods have been validated in the literature. In the last few years, identification of T cell activation markers to assess drug allergy has been the focus of several studies. Objective: The aim of the present work was to search for CD25 and CD69 markers on T CD4+ and T CD8+ cells in drug allergy. Methods: Fourteen patients with drug hypersensitivity were enrolled in this investigation. Some patients had at least one adverse reaction to one or more suspected drugs, therefore, a total of 16 reactions and 10 drugs were investigated. Prick or patch tests were done according with the time of onset and type of the clinical manifestations. In vitro studies were performed by incubating peripheral blood mononuclear cells from patients and controls wi.. View More»
  DOI: 10.4172/2329-6887.1000111

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