Journal of Clinical & Experimental Pharmacology

Franciska Erdő

Publications

• Review Article
  Microdialysis Techniques In Pharmacokinetic and Biomarker Studies. Past, Present and Future Directions. A Review.
  Author(s): Franciska ErdőFranciska Erdő
  
  Microdialysis (MD) techniques were first applied in the early 1960s. The fields of their application comprised probe implantation into the central nervous system (CNS) at the beginning, and then expanded to almost every organ summarized in this article. After its early experimental applications MD became an important tool in the human pharmacokinetic/pharmacodynamic (PK/PD) studies as well. This monitoring technique is capable for investigation of local unbound concentrations of both endogenous and exogenous compounds in the interstitial fluid. The review shows examples for the role of MD in pharmacodynamic studies and for its use in tissue distribution and drug-transporter interaction studies. Determination of test substances in the dialysate samples needs sensitive bioanalytical methods. The main analytical techniques coupled with MD are summarized under the subtitle “Target m.. View More»
  DOI: 10.4172/2161-1459.1000180

  Abstract PDF