Natural Products Chemistry & Research

ISSN - 2329-6836

Fernando Gonzalez

Fernando Gonzalez
Arizona College of Osteopathic Medicine,
19555 N. 59th Avenue, Glendale, AZ 85308
Tanzania

Publications
  • Research Article
    Green Tea Extract Induces Apoptosis in the AGS Gastric Carcinoma Cell Line
    Author(s): Fernando GonzalezFernando Gonzalez

    Green tea has long been thought to possess anticancer properties. Additionally, the polyphenol components of green tea have demonstrated ability to inhibit 26S proteasome function. As there have been reports describing varied responses of gastric carcinoma cells to green tea treatment, the role of green tea treatment on proteasome function in the gastric carcinoma cell line AGS was investigated. Presented here are findings demonstrating that green tea extract is capable of inhibiting proteasome function of AGS cells. Furthermore, treatment of AGS cells with the green tea polyphenol (-)-Epigallocatechin-3-gallate resulted in a similar level of proteasome inhibition. It was also discovered in this study that proteasome inhibition in AGS cells resulted in a buildup of Kip1/p27 and IκBα, proteins that are involved in the progression through the G1/S checkpoint during cell divi.. View More»

    DOI: 10.4172/2329-6836.1000130

    Abstract PDF

Relevant Topics

Top