Biochemistry & Analytical Biochemistry

Fen Liu

Publications

• Research Article
  Single Nucleotide Polymorphism of the CYP2J2 Gene is Associated with Essential Hypertension in Uygur Population in China
  Author(s): Qing Zhu, Ali Amjad, Zhenyan Fu, Yitong Ma, Ding Huang, Xiang Xie and Fen LiuQing Zhu, Ali Amjad, Zhenyan Fu, Yitong Ma, Ding Huang, Xiang Xie and Fen Liu
  
  Background: Human Cytochrome P450 2J2 (CYP2J2) is the major arachidonic acid epoxygenase, which can metabolizes arachidonic acid (AA) to biologically active epoxyeicosatrienoic acids (EETs). The EETs are potent endogenous vasodilators and inhibitors of vascular inflammation. Recently, many evidence from models and human studies suggests that variability of CYP2J2 gene plays a mechanistic role in the development of hypertension. The aim of the present study was to assess the association between the human CYP2J2 gene polymorphism and Essential Hypertension (EH) in a Han and Uygur population in China. Methods: We used two independent case-control studies: a Han population (302 EH patients and 300 control subjects) and a Uygur population (567 EH patients and 215 control subjects). All EH patients and controls were genotyped for the same three si.. View More»
  DOI: 10.4172/2161-1009.1000159

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