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Federico Benetti
Federico Benetti
ECSIN-European Center for the Sustainable Impact of Nanotechnology,
Veneto Nanotech S.C.p.A., Viale Porta Adige 45, I-45100 Rovigo
Italy
Publications
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Research Article
Analysis of Operating Conditions Influencing the Morphology and In vitro Behaviour of Chitosan Coated Liposomes
Author(s): Marco Venturini, Stefania Mazzitelli, Ivan Micetic, Camilla Benini, Jacopo Fabbri, Stefano Pozzi Mucelli, Federico Benetti and Claudio NastruzziMarco Venturini, Stefania Mazzitelli, Ivan Micetic, Camilla Benini, Jacopo Fabbri, Stefano Pozzi Mucelli, Federico Benetti and Claudio Nastruzzi
Among nanoparticle-based drug delivery formulations, lecithin/chitosan liposomes are promising candidates because of their biocompatibility, biodegradability and bioadhesion properties. Lecithin is a mixture of highly biocompatible phospholipids, while chitosan represents one of the most used polymers in pharmaceutical formulations. Their combination results in positively charged complexes that are able to sustain a specific, prolonged and controlled release. Scarce reproducibility and batch-to-batch variation in lecithin/chitosan liposome synthesis, as well as difficult scale-up to industrial production, is a major challenge for their utilization. Here we present a strictly controlled procedure, based on ethanol diffusion in water, which yields to a precise and reproducible self-organization of lecithin and chitosan molecules. We analysed the size, surface charge and stability of chi.. View More»
DOI: 10.4172/2157-7439.1000211