Journal of Allergy & Therapy

Journal of Allergy & Therapy
Open Access

ISSN: 2155-6121

Enrico Crivellato

  • Review Article
    Cooperation of Mast Cells and Basophils in Allergy
    Author(s): Enrico Crivellato and Domenico RibattiEnrico Crivellato and Domenico Ribatti

    Mast cells and basophils are granulated cells, which share similar phenotypic and functional properties. They express complementary and partially overlapping roles in acquired and innate immunity, including both effector and regulatory activities, but they also display important distinctive features as to developmental lineage, mediator content, and function. They cooperate in expanding and/or modulating inflammation as well as in mediating subsequent tissue repair. Mast cells release in the inflammatory scenario a series of potent proangiogenic molecules that stimulate vessel sprouting and new vessel formation. Recent data suggest that basophils may also play a role in inflammation-related angiogenesis, principally but not exclusively through the expression of several forms of VEGF and their receptors. This review focuses on the potential cooperative link between mast cells and basop.. Read More»
    DOI: 10.4172/2155-6121.1000135

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