Journal of Vaccines & Vaccination

Journal of Vaccines & Vaccination
Open Access

ISSN: 2157-7560

Ennio Duranti

  • Short Communication
    HBV Vaccination in the Patient with Chronic Renal Disease
    Author(s): Ennio Duranti and Diletta DurantiEnnio Duranti and Diletta Duranti

    Patients undergoing hemodialysis often present with a reduced response to anti-hepatitis B virus (anti-HBV) vaccination. The soluble form of CD40 (sCD40) is elevated in hemodialysis patients and this has been shown to correlate with lack of response to anti-HBV vaccination. Due to its high molecular weight, conventional dialyzers cannot clear sCD40. Dialysis membranes in polymethylmethacrylate (PMMA) can reduce the levels of sCD40. We have used PMMA membranes in patients who were non-responders to anti-HBV vaccination (anti-HB antibody level<10 UI/L after 2 vaccinations circles). Interestingly, we found that significantly more patients in the PMMA group were able to mount a response to vaccination, compared to the control group. .. Read More»
    DOI: 10.4172/2157-7560.1000386

    Abstract PDF

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