Journal of Clinical & Experimental Pharmacology

El-Sayyad HI

Publications

• Review Article
  Type 2 Diabetes and Developmental Origin of Non-Alcohol Fatty Liver Disease and Future Directions of Treatment
  Author(s): El-Sayyad HI and El-Shahary EAEl-Sayyad HI and El-Shahary EA
  
  Non-alcohol fatty liver disease is a large public health problem developed earlier during intrauterine life as a result of gestational or type 2 diabetes. The disease is associated with altered liver enzymes, lipid accumulation and hepatic steatosis due to hepatic de novo lipogenesis. Multiple factors are associated in the development of the disease such as peroxisome proliferator-activated receptor-? co-activator, B-cell dysfunction and abnormal metabolism of mitochondria, lysosomes, rough endoplasmic reticulum and Golgi complex. These factors are discussed in details. Different approaches of drug-treatment, phyto-& gene therapy are illustrated. Role of type 2 or gestational diabetes on developmental origin of fatty liver. The interrelation-ship between type 2 diabetes and obesity and fetus's liver. Role of cytoplasmic organelles in de novo lipogenesis, inflammation, and hepatocyte cell.. View More»
  DOI: 10.4172/2161-1459.1000220

  Abstract PDF