Journal of Allergy & Therapy

Eijin Sutoh

Publications

• Research Article
  Interleukin (IL)-13, IL-17A, and Mast Cell Chymase Gene Polymorphisms in Bronchial Asthma and Chronic Obstructive Pulmonary Disease - A Pilot Study in a Japanese Population
  Author(s): Motohiro Kurosawa, Eijin Sutoh and Yujin SutohMotohiro Kurosawa, Eijin Sutoh and Yujin Sutoh
  
  Background: Chronic obstructive pulmonary disease (COPD) and bronchial asthma might have common genetic factors. Interleukin 13 (IL-13) gene polymorphism has been suggested to be one of the candidates; however inconsistent results have been reported. Studies of the gene polymorphisms in IL-17A gene and mast cell chymase gene (CMA1) in COPD and bronchial asthma have not been reported. Methods: The single nucleotide polymorphisms in IL-13 -1111C>T, IL-13 Arg130Gln, IL-17A -737C>T, and CAM1 -1903G>A genes were examined in 100 COPD patients, 250 asthmatics and 100 normal control. All patients were Japanese who were in a stable condition. Results: The frequency of TT/CT genotype of the IL-13 -1111C>T was higher than that of CC genotype in COPD patients compared with asthmatics. Subgroup analyses with gender showed that in female COPD patients the frequency of TT/CT genotype of .. View More»
  DOI: 10.4172/2155-6121.1000224

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