Biochemistry & Analytical Biochemistry

Egwim EC

Publications

• Research Article
  Effects of High and Low Glycemic Load of Different Nigerian Food Forms on Rats Brain and Heart Mitochondrial Integrity
  Author(s): Egwim EC and Yakubu GEgwim EC and Yakubu G
  
  The present study was designed to investigate the effect of glycemic load (GL) on brain and cardiac mitochondrial integrity. The effect of high glycemic load (HGL) and low glycemic load (LGL) diets on the generation of free radicals and its consequent effect on brain and cardiac mitochondrial were assessed. The effect of the reactive oxygen species (ROS) on the activities of electron transport chain (ETC) was examined. A significant decline in enzyme activities of complex I, III and IV were observed, for both brain and cardiac mitochondria ETC. Brain rotenone-sensitive complex I activities decreased by 49.20% (p>0.05) in HGL-fed rats, while antimycin-a sensitive complex III decreased by 19.80% (p>0.05). Same phenomenon was observed in potassium cyanide (KCN)-sensitive complex IV (cytochrome c oxidase), which decreased by 30.17% (p>0.05). For cardiac mitochondrial complexes, R.. View More»
  DOI: 10.35248/2161-1009.19.8.377

  Abstract PDF