Biochemistry & Analytical Biochemistry

DP Singh

Publications

• Research Article
  Genome-Wide Relative Analysis of Codon Usage Bias and Codon Context Pattern in the Bacteria Salinibacter Ruber, Chromohalobacter Salexigens and Rhizobium Etli
  Author(s): Mohammad Samir Farooqi, DC Mishra, Niyati Rai, DP Singh, Anil Rai, KK Chaturvedi, Ratna Prabha and Manjeet KaurMohammad Samir Farooqi, DC Mishra, Niyati Rai, DP Singh, Anil Rai, KK Chaturvedi, Ratna Prabha and Manjeet Kaur
  
  Codon is the basic unit for biological message transmission during synthesis of proteins in an organism. Codon Usage Bias is preferential usage among synonymous codons, in an organisms. This preferential use of a synonymous codon was found not only among species but also occurs among genes within the same genome of a species. This variation of codon usage patterns are controlled by natural processes such as mutation, drift and pressure. In this study, we have used computational as well as statistical techniques for finding codon usage bias and codon context pattern of Salinibacter ruber (extreme halophilic), Chromohalobacter salexigens (moderate halophilic) and Rhizobium etli (nonhalophilic). In addition to this, compositional variation in translated amino acid frequency, effective number of codons and optimal codons were also studied. A plot of ENc versus GC3s suggests that both muta.. View More»
  DOI: 10.4172/2161-1009.1000257

  Abstract PDF