Journal of Liver

Donna L George

Publications

• Research Article
  The p53 Codon 72 Polymorphism Modifies the Cellular Response to Inflammatory Challenge in the Liver
  Author(s): Julia I-Ju Leu, Maureen E Murphy and Donna L GeorgeJulia I-Ju Leu, Maureen E Murphy and Donna L George
  
  The p53 protein is a critical stress-response mediator and signal coordinator in cellular metabolism and environmental exposure to deleterious agents. In human populations, the p53 gene contains a common single nucleotide polymorphism (SNP) affecting codon 72 that determines whether a proline (P72) or an arginine (R72) is present at this amino acid position of the polypeptide. Previous studies carried out using human populations, mouse models, and cell culture analyses have provided evidence that this amino acid difference can alter p53 functional activities, and potentially also can affect clinical presentation of disease. The clinical presentation associated with many forms of liver disease is variable, but few of the responsible underlying genetic factors or molecular pathways have been identified. The aim of the present study was to investigate whether the p53 codon 72 polymorphis.. View More»
  DOI: 10.4172/2167-0889.1000117

  Abstract PDF