Journal of Pharmacovigilance

Devendhar Reddy Komalla

Publications

• Research Article
  Design and Evaluation of Floating Multi Unit Mini Tablets (MUMTS) Muco Adhesive Drug Delivery System of Famotidine to Treat Upper Gastro Intestinal Ulcers
  Author(s): Nagaraju Banala, Mahipal Reddy Donthi, Narendhar Reddy Dudipala, Devendhar Reddy Komalla, Dinesh Suram and Vinay ThallapallyNagaraju Banala, Mahipal Reddy Donthi, Narendhar Reddy Dudipala, Devendhar Reddy Komalla, Dinesh Suram and Vinay Thallapally
  
  Ulcer is one of the most common evaluated diseases caused by many reasons like, H. pylori bacteria infection, over secretion of acid levels in the stomach, irregular formation of mucosa and some of the NSAIDs treatment. Famotidine is a H2 receptor antagonist, used to reduce the gastric acid secretion in the stomach. The aim of the present investigation was the development and evaluation of famotidine multi-unit tablet encapsulated system to treat upper gastro intestinal ulcers. The drug release was controlled with matrix polymers like POLYOXWSR 1105 and HPMC K4M. The tablets were prepared by direct compression technique. The prepared tablets were evaluated for physico chemical parameters like weight variation, hardness, friability, buoyancy studies, drug content, in vitro dissolution and mucoadhesive property in porcine.. View More»
  DOI: 10.4172/2329-6887.1000179

  Abstract PDF