Denise L Faustman
Massachusetts General Hospital, Harvard Medical School,
Building 149, 13th Street, Room 3602, Boston, MA 02129
Tanzania
Research Article
Possible Transient Benefits of Epstein Barr Virus Infection in Three Subjects with Established Type 1 Diabetes
Author(s): Willem M Kühtreiber, Sophie L Leung, Limei Wang, Elise Hsu, Peter E Reinhold III, Menghan Zhao, Hui Zhang, Douglas E Burger and Denise L FaustmanWillem M Kühtreiber, Sophie L Leung, Limei Wang, Elise Hsu, Peter E Reinhold III, Menghan Zhao, Hui Zhang, Douglas E Burger and Denise L Faustman
Tumor necrosis factor (TNF) is a novel immunotherapy for type I diabetes because it selectively kills insulin autoreactive T-cells, which enables recovery of insulin production by pancreatic islet cells. The TNF inducer Bacillus Calmette-Guerin (BCG) also has therapeutic value by activating innate immunity that beneficially modifies the course of type 1 diabetes (T1D) in the same manner as TNF. Epstein Barr Virus (EBV) infection is also an inducer of TNF. This observational study was undertaken to determine whether EBV has the same beneficial effects as BCG in a recent clinical trial. We describe three cases of long-term diabetic subjects with active mononucleosis that were followed for 15 weeks to determine the impact of EBV infection on established T1D. In comparison to non-EBVinfected long-term diabetics, EBV transiently diminished the autoimmune r.. View More»
