Biology and Medicine

Den-Chang Wu

Publications

• Research Article
  Risk of Chronic Kidney Disease after Early and Late Helicobacter Pylori Eradication in Patients with Peptic Ulcer Disease: A Population-Based Cohort Study in Taiwan
  Author(s): Guei-Fen Chiu, Yu-Han Chang, Den-Chang Wu, Ming-Tsang Wu and Hugo You-Hsien LinGuei-Fen Chiu, Yu-Han Chang, Den-Chang Wu, Ming-Tsang Wu and Hugo You-Hsien Lin
  
  Background: Helicobacter pylori play a central role in the development of chronic gastritis, gastric and duodenal ulcers, and gastric cancer. The risk of upper gastrointestinal bleeding in patients with chronic kidney disease (CKD) or end stage renal disease is reportedly higher than that in the general population. The effects of early and late H. pylori eradication on kidney disease rates warrant further investigation. Methods: We conducted a population-based study by using Taiwan’s National Health Insurance Research Database of 1 million beneficiaries. The enrolled-date of this database is from January 1, 2000 to December 31, 2009. We compared the incidence and risk of CKD in 3,689 patients in the early H. pylori eradication cohort with those in 4,298 patients in the late H. pylori eradication cohort. Results: The adjusted hazard ratio (HR; 95% confidence interval (CI)=1.17&nd.. View More»
  DOI: 10.4172/0974-8369.1000402

  Abstract PDF