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Deepak Gopal Shewade
Deepak Gopal Shewade
India
Publications
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Review Article
Single Nucleotide Polymorphisms as Biomarkers for Drug Response and Toxicity in the Management of Colorectal Cancer
Author(s): Ashok Varma, Mathaiyan Jayanthi and Deepak Gopal ShewadeAshok Varma, Mathaiyan Jayanthi and Deepak Gopal Shewade
The current methods of cancer treatment don’t focus on the influence of interpatient genetic variations on the treatment outcomes. Genetic variations in the genes which are involved with drug metabolism and targets can affect treatment response and toxicity. In the recent time, many advances have been made to detect such candidate gene variations and use them as biomarkers in predicting the treatment outcomes in colorectal cancer (CRC). CRC remains one of the common causes of worldwide morbidity and mortality. In the last decade, many drugs have been approved including targeted therapies for the management of CRC which lead to improvement in the median survival and overall survival rate. However, there are significant variations in the response rate and toxicity among CRC patients with the current anti-cancer drugs. Interindividual response variations to chemotherapy can be infl.. View More»
DOI: 10.4172/2153-0645.1000178