De Ledinghen V
France
Research Article
Steatosis, Glycation and Liver Fibrosis in Patients with Diabetes
Author(s): Marty M, Hiriart HB, Vergniol J, Foucher J, De Ledinghen V, Gin H and Rigalleau VMarty M, Hiriart HB, Vergniol J, Foucher J, De Ledinghen V, Gin H and Rigalleau V
Introduction: Non Alcoholic Fatty Liver Disease (NAFLD) is frequent and progresses to fibrosis among patients with diabetes. The roles of hepatic steatosis and of the accumulation of Advanced Glycation Endproducts (AGEs) can now be analyzed by new non-invasive methods. Patients and methods: Among hospitalized patients with diabetes, we assessed liver fibrosis by liver stiffness measurement (LSM), steatosis by the attenuation coefficient of an ultrasonic wave (CAP) and AGE accumulation by skin autofluorescence (sAF). The patients with severe fibrosis were compared to the others by ANOVA and Chi-2, and the relations between fibrosis, steatosis, and skin AF were studied by regression analysis. Results: 178 patients were included: 60% male, age 59 ± 11 years, BMI 31 ± 6 kg/m2, 79% with Type 2 Diabetes (T2D), poorly controlled (HbA1C 9.0 ± 2.4%). sAF were available in .. View More»
