David A. Rubenstein
School of Mechanical and Aerospace Engineering,
218 Engineering North, Stillwater, OK 74078-5016
Tanzania
Research Article
Glycated Albumin and Pathological Shear Stress Alters Endothelial Cell Thrombogenic Potential, Pro-Inflammatory State and Cytoskeletal Dynamics
Author(s): Zahra Maria, Wei Yin and David A. RubensteinZahra Maria, Wei Yin and David A. Rubenstein
Background: Diabetes mellitus is a disease that is characterized by a high blood glucose concentration, which leads to advanced glycation end product (AGE) formation. AGEs have various effects on the vasculature and this may be dependent on the extent and reversibility of glycation. AGEs present in the vasculature can promote cardiovascular diseases through modifications to circulating proteins and endothelial cells. Furthermore, cardiovascular diseases are characterized by altered shear stress, including both high magnitude short duration shear and low oscillatory shear. However, the combined role of high magnitude shear stress and the presence of AGEs on endothelial cell functions have not been elucidated. Our objective was to evaluate changes to endothelial cell responses under these conditions.
Methods: To accomplish this, albu.. View More»
